http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108299422-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2018-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108299422-B |
| titleOfInvention | A kind of preparation method of pa pool former times benefit cloth intermediate |
| abstract | The present invention relates to pharmaceutical synthesis fields, disclose a kind of preparation method of pa pool former times benefit cloth intermediate, in preparation process of the present invention, with 5- bromo- 2,4- dichloro pyrimidine is starting material, promote ground palladium catalysed cross coupling reaction, BTC to promote ground cyclization reaction and NBS bromo-reaction by ammonification substitution reaction, green solvent PEG, finally obtains target compound V, and by the improvement to post-processing so that the HPLC purity of final product is up to 99% or more.Compared with traditional handicraft, beneficial effect of the present invention is mainly reflected in: mild, easy to operate, palladium catalyst the dosage of reaction condition is lower, high income, at low cost, " three wastes " amount less, be easy to industrialize, there are biggish implementary value and economic results in society. |
| priorityDate | 2018-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 103.