| abstract |
The present invention provides chemical entities of formula (I) and compositions comprising such chemical entities; methods for their manufacture; and their use in a variety of methods including metabolic and reaction kinetics studies, detection and imaging techniques, and radiation therapy; and therapies, including inhibiting PDE4, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating cognitive impairment associated with CNS disorders, enhancing the efficiency of cognitive and motor training, providing neurorehabilitation and neurorehabilitation , enhancing the efficiency of non-human animal training programs, and treating peripheral conditions, including inflammatory and renal disease. |