abstract |
The invention discloses a class of 2,3,4-trihydroxybenzenesulfonamide derivatives, a preparation method and application thereof, and its specific structural formula is shown in formula (I). Most of the 2,3,4-trihydroxybenzenesulfonamide derivatives in formula (I) exhibit good anti-interleukin IL-17A activity. IL-17A is not only related to autoimmune diseases, but also related to the occurrence and development of cancer. Based on this, the above-mentioned 2,3,4-trihydroxybenzenesulfonamide derivatives can be used to prepare immunomodulatory drugs. |