| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 |
| filingDate |
2016-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2020-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2020-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-108290872-B |
| titleOfInvention |
Cyanopyrrolidine derivatives as DUBs inhibitors |
| abstract |
The present invention relates to novel compounds and methods for preparing Deubiquitinase (DUB) inhibitors. In particular, the present invention relates to methods of inhibiting Cezanne1 and ubiquitin C-terminal hydrolase 30 or ubiquitin-specific peptidase 30(USP 30). The invention also relates to the use of DUB inhibitors in the treatment of cancer. The compounds of the present invention include compounds having the formula (I): or a pharmaceutically acceptable salt thereof, wherein R 1a 、R 1b 、R 1c 、R 1d 、R 1e 、R 1f And a is as defined herein. |
| priorityDate |
2015-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |