http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108283721-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-225 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-22 |
| filingDate | 2018-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108283721-B |
| titleOfInvention | HA-mediated CPPs-modified 10-HCPT-loaded phase-change lipid nanoparticles and preparation method thereof |
| abstract | The invention discloses a 10-HCPT-loaded phase transition lipid nanoparticle modified by HA mediated by CPPs, comprising a phospholipid shell membrane, an antitumor drug 10-HCPT is loaded on the phospholipid shell membrane, and DC-cholesterol is modified on the phospholipid shell membrane. The penetrating peptide linked with cysteine and hyaluronic acid are adsorbed on the outer layer of the phospholipid shell membrane. The technical problem to be solved by the present invention is to provide a method that can specifically and actively target and enter the deep liver cancer tissue, can undergo liquid-gas phase transition under the irradiation of LIFU in vitro, and can simultaneously perform real-time imaging and localized release of anti-tumor drugs Preparation method of HA-mediated CPPs-modified phase-change lipid nanoparticles loaded with 10-HCPT. |
| priorityDate | 2018-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.