http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108276564-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G63-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-3322 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-331 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-332 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-331 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 |
| filingDate | 2018-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108276564-B |
| titleOfInvention | Preparation method of multi-block temperature-sensitive material containing maleic anhydride |
| abstract | The invention discloses a preparation method of a multi-block temperature-sensitive material containing maleic anhydride, which comprises the following steps: synthesizing a maleic anhydride-polyoxyethylene-oxypropylene block copolymer (MA-Fm-MA); purifying a crude product; synthesizing PLGA-MA-Fm-MA-PLGA; preparing a nanogel material; preparation of physical gel. According to the invention, through a nano gel technology and a macroscopic physical gel synthesis technology, the drug loading capacity of the hydrophobic segment micelle is improved, and the drug release controllability is improved. In the synthesis of the temperature-sensitive material, a novelty introduced functional monomer is used as an activator of a macromonomer on one hand, and a series of copolymers are formed by utilizing a ring-opening polymerization mode of lactide and the like by utilizing a cyclic anhydride structure contained in a molecule; on the other hand, unsaturated double bonds contained in the functional monomers are utilized to form chemical crosslinking among macromolecular chains forming the nanogel, so that a stable three-dimensional network structure is formed, and the stability of the system is improved. |
| priorityDate | 2018-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.