| abstract |
The invention belongs to the field of medicinal chemistry, and relates to a class of compounds used as cyclin-dependent kinase inhibitors (CDKs) and applications thereof. Specifically, the present invention provides a compound represented by formula I or an isomer thereof, which is pharmaceutically acceptable The salts, solvates, crystals or prodrugs of these compounds, their preparation methods and pharmaceutical compositions containing these compounds and the use of these compounds or compositions for the treatment of cancer, tissue proliferative diseases or inflammatory diseases. The compounds of the present invention have good inhibitory activity on CDK7, and are very promising as therapeutic agents for cancer, tissue proliferative diseases and inflammatory diseases. |