| abstract |
The invention provides a method for preparing sulfonamide antibiotics labeled with benzene ring 14 C. The aniline hydrochloride labeled with benzene ring 14 C is used as an initial reactant, and undergoes acetylation reaction, chlorosulfonation reaction, condensation reaction and hydrolysis reaction, The sulfonamide antibiotics labeled with benzene ring 14 C were prepared. The preparation method provided by the present invention adopts silica gel column chromatography or silica gel plate chromatography to purify the materials obtained after each step of reaction, and finally can obtain trace-level (mg) sulfonamide antibiotics labeled with benzene ring 14 C, which avoids the need to refer to constant synthesis. The problem that the product cannot be obtained by purifying by water crystallization method. At the same time, the present invention uses an organic solvent and adds molecular sieves in the condensation reaction, which ensures that the condensation reaction in the radioactive microsynthesis can proceed smoothly under anhydrous conditions, and the operation is simple and convenient. |