| abstract |
The present invention provides a kind of antitumor medicine composition, described pharmaceutical composition includes at least one isothiocyanate derivatives and at least one iron preparation.Antitumor medicine composition provided by the invention contains at least one isothiocyanate derivatives and at least one iron preparation.In isothiocyanate derivatives combination GSH, under the premise of improving oxidation level, after the iron preparation enters in vivo, the thermophilic iron characteristic of tumour cell can dramatically increase the Fe in tumour cell body 2+ Content, Fe 2+ Fenton's reaction is participated in, ROS is further generated, and then inhibit intracellular GSH antioxidant systems, breaks Redox homeostasis, intracellular ROS is maintained into higher level.ROS can occur peroxidatic reaction of lipid with lipid and generate lipid ROS, and ROS not only damages lipid and protein, but also can cause DNA damage, promotes the death of cell. |