http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108264509-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 |
| filingDate | 2016-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108264509-B |
| titleOfInvention | Substituted benzothieno [2,3-c ] tetrahydropyridine derivatives, preparation method and application thereof |
| abstract | The invention belongs to the technical field of pharmaceutical chemistry and medicine, and relates to substituted benzothieno [2,3-c ] shown as a formula (I)]Tetrahydropyridine derivatives, processes for their preparation and their use in medicine as inhibitors of CYP17, compositions containing them and methods of their use. The invention further relates to pharmaceutical compositions comprising at least one such compound for use in the treatment of CYP17 enzyme-related disorders such as cancer and other proliferative diseases. In formula I, X is a substituent of S, NH and N, R 1 Including but not limited to H, halogen, -OH, -CN, -0R a ,‑NR a R b ,‑NHCOR a OR-C (O) OR a From 0 to 4R a Substituted C 1‑6 Alkyl, by 0 to 4R a Substituted C 3‑6 Cycloalkyl radical, by 0 to 6R b Substituted aryl and C 1‑6 Fluoroalkyl or C 3‑6 Fluorocycloalkyl group, R 2 Including, but not limited to, substituted imidazolyl and substituted pyridyl and pyrimidinyl; and R1, R2, Ra, Rb and Rc are as defined herein. |
| priorityDate | 2016-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 572.