| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18d39a9dd64d2057ca09c6acc124fc58 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C201-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C29-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-33 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C201-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-675
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C29-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C31-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-28 |
| filingDate |
2017-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a292ed91a9836cffd5f7edca4fc61c04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f49e19900e1d23e6f7c12589b95d25c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fb83d8aa6d14386bc0400a9bb65a242 |
| publicationDate |
2018-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-108264495-A |
| titleOfInvention |
Bu Waxitan chiral intermediates and preparation method thereof |
| abstract |
The present invention relates to a kind of anti-epileptic stype Wa Xitan chiral intermediates and preparation method thereof, the preparation method of compound is shown in Bu Waxitan chiral intermediates formula 1 of the present invention：With S epoxychloropropane（7 compound of formula）For starting material and ethyl metal reagent, 6 compound of formula is prepared in open loop under lewis acid effect；5 compound of formula is prepared by substitution reaction in the presence of metallic catalyst in 6 compound of formula；The cyano alcoholysis in the case where acid acts on of 5 compound of formula is 4 compound of formula；3 compound of formula is prepared through the effect of hydroxy activated reagent in 4 compound of formula；3 compound of formula is with nitromethane through SN 2 2 compound of formula is prepared in nucleophilic substitution；2 compound of formula used in the concentrated sulfuric acid reacted by Nef, 1 compound of Bu Waxitan chiral intermediates formula is prepared in cyclization.The preparation method of the present invention can prepare 1 compound of high-optical-purity formula, and preparing 1 compound of high-optical-purity formula by the method and solving production Bu Waxitan at present needs the higher unit operation of the complexity such as column chromatography, chiral preparatory column, cost. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019239341-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111592460-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112143764-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113717132-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113717132-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110357790-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112143764-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IT-201800006320-A1 |
| priorityDate |
2017-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |