| abstract |
The invention discloses a kind of multiple target point Chimeric antigen receptors.The present invention provides multiple target point Chimeric antigen receptors, are made of main peptide chain and auxiliary peptide chain；The main peptide chain includes antigen binding domain A, auxiliary peptide chain link field B, transmembrane domain C and intracellular signal transduction structural domain D；The auxiliary peptide chain includes main peptide chain link field F；The antigen binding domain A is with the polypeptide for combining antigen function；The auxiliary peptide chain link field B and the main peptide chain link field F be combined with each other；The transmembrane domain C is the membrane-spanning domain of arbitrary embrane-associated protein or the membrane-spanning domain of transmembrane protein；The intracellular signal transduction structural domain D includes primary signal conducting region.The multiple target point Chimeric antigen receptor of the present invention by two antigen binding domain and different antigen bindings, can mediate the cell killing of specificity；And cell factor and cytokine receptor complex are introduced in the multiple target point Chimeric antigen receptor of the present invention, they can play the function of cell factor. |