http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108250196-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2016-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108250196-B |
| titleOfInvention | The preparation method of (piperazin-1-yl)-1 hydrogen-imidazoheteroaromatic ring compound |
| abstract | The invention provides a preparation method of -(piperazine-1-yl)-1 hydrogen-imidazoheteroaromatic compound shown in formula I, Wherein, X, Y, and Z are optionally selected from carbon atoms or nitrogen atoms, and Pg is a protecting group; the method comprises the following steps: subjecting compound formula II to a catalyst, an acid, a trialkyl orthoformate, and a hydrogen source The reaction is carried out to obtain the compound of formula I. The present invention improves the prior art, and the purity and purity of the product obtained by the preparation method of the present invention are high, avoiding the need for step-by-step reactions in the prior art, thereby requiring separation or purification of unstable diamine intermediate M, resulting in The disadvantage of the reduced yield and purity of the preparation of the compound of formula I. |
| priorityDate | 2016-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 87.