http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108239664-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-04 |
| filingDate | 2018-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108239664-B |
| titleOfInvention | Process for preparing 4-hydroxy-L-threonine |
| abstract | The invention relates to the technical field of biochemistry, and discloses a process for preparing 4-hydroxy-L-threonine by an immobilized enzyme tandem method. The invention utilizes L-threonine activating enzyme to couple L-threonine aldolase to complete conversion, adopts Adk and PaP or fusion protease thereof and cheap polyphosphoric acid to regenerate ATP in a timely and cyclic manner, has simple reaction process, convenient operation and stable product quality, better realizes the continuous conversion of raw materials and the regeneration of coenzyme ATP, can be circularly utilized for a plurality of times by matching with stable immobilized enzyme, thereby greatly reducing the production cost. The process effectively avoids the complicated processes of multi-step group protection, chiral separation and the like in the chemical synthesis technology, simultaneously avoids the influence of metabolites, proteins and other impurities on the purification of later-stage products caused by microbial fermentation, and is very suitable for industrial large-scale production. |
| priorityDate | 2018-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1689.