| abstract |
The present invention provides a kind of multipotential stem cell and its T cell and application of differentiation, the multipotential stem cell includes Runx1 and Hoxa9 series connection coexpression vector.External source Runx1 and Hoxa9 coexpression vector is introduced into multipotential stem cell by the present invention, successfully constructs the multipotential stem cell of inductivity coexpression external source Runx1 and Hoxa9, the multipotential stem cell directed differentiation is T pedigree progenitor cells, and will be developed for T cell.Using the T cell in the multipotential stem cell source that method of the invention obtains, not only function is normal, but also does not have tumorigenesis risk. |