| abstract |
The invention belongs to the field of medicinal chemistry, and in particular relates to a class of optical isomers of nucleoside phosphoramidate compounds or hydrates, solvates, crystals or pharmaceutically acceptable salts thereof, their preparation methods and compositions containing these compounds The pharmaceutical composition and the use of these compounds or compositions as a drug for treating viral infectious diseases, especially as a drug for treating viral hepatitis. Experimental results show that the compound of the present invention exhibits good inhibitory activity on hepatitis C virus subtype 1b and subtype 1a, and has very low toxicity to host cells, high effectiveness and good safety, and is suitable for treatment and/or Prevention of diseases associated with HCV infection. |