http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108218824-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D313-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D313-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-335 |
| filingDate | 2016-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108218824-B |
| titleOfInvention | Diphenyl [ b, d ] oxepane compound and preparation and application thereof |
| abstract | The invention belongs to the technical field of organic synthesis, and relates to a method for synthesizing diphenyl [ b, d ] by using a lignin model compound]A method of producing an oxepane compound. The compound has the following structural formula: wherein R is 1 ，R 2 ，R 3 ，R 4 is-H or-OCH 3 ，R 5 ＝‑CH 2 CH 2 CH 3 ，‑CH 2 CH 2 COOCH 3 ，‑CH 2 CH 2 COOH，‑CH 2 CH 2 CH 2 OH，‑CH 3 or-CHO, the preparation method of the invention takes lignin β -O-4 dimer model compound as raw material, and diphenyl [ b, d ] is obtained by oxidative coupling reaction]An oxepane compound. Prepared diphenyl [ b, d ]]The oxepane compound has the activity of resisting tumor cells and inhibiting the activity of rat liver microsome cytochrome P450, and the invention firstly develops the synthesis of diphenyl [ b, d ] by taking lignin β -O-4 model compound as raw material]The method for preparing the oxepane compound has the advantages of simple operation, mild reaction conditions, environmental friendliness, simple post-treatment, high yield and good industrial production prospect. |
| priorityDate | 2016-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 127.