http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108218771-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e9f89888856cc79683d828d90e94a9f7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-22 |
| filingDate | 2018-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef497036d6b7112504d7e16050a080d9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db277544ef024e14fb1c6bb279a7cd49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bc225929cb874292c9162719aabbab6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aca3c7a981900de5e05e1304b28884d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b79e6633a6ff979abf21681119e2e301 |
| publicationDate | 2018-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108218771-A |
| titleOfInvention | Deuterated aripiprazole and its preparation method and use |
| abstract | The invention belongs to the field of organic and pharmaceutical synthesis, and discloses a deuterated d8 aripiprazole and its preparation method and application. The method uses 1,4-dichlorobutane- d8 as a raw material and synthesizes it through four steps of reaction Deuterium-labeled d8-aripiprazole; the preparation method provided by the present invention has reasonable design of the whole process, strong operability, simple operation, low cost of deuterium reagent, easy separation and purification of the product, and the obtained target product has stable chemical properties and isotope The abundance is high, the yield is high, and the purity can reach 100%. The preparation method of the present invention can be used to produce the deuterated internal standard used in the analysis and detection of deuterated aripiprazole, and can provide a sample for the study of the metabolic mechanism of aripiprazole, thereby more accurately and conveniently understanding the deuterated aripiprazole Metabolic process and mechanism of action in the human body; pharmaceutical composition can be prepared for dopamine system stabilizer-treatment of schizophrenia, schizoaffective psychosis and other psychotic disorders, etc., which has important application value. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112608226-A |
| priorityDate | 2018-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.