http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108210918-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-948 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-19012 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4813 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 |
| filingDate | 2018-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108210918-B |
| titleOfInvention | Application of deubiquitinase 1 containing OTU functional domain in preparation of drugs for treating fatty liver and related diseases |
| abstract | The invention discloses an application of deubiquitinating enzyme 1 containing OTU functional domain in preparing medicine for treating fatty liver and related diseases. The invention takes a normal human hepatocyte L02 cell line as a research object, and utilizes lentivirus to construct an OTUD1 knockdown and over-expression vector system to obtain an OTUD1 gene knocked-down or over-expressed L02 cell. The function of the OTUD1 gene in steatosis is studied by a fatty liver cell model induced by combination of Palmitic Acid (PA) and Oleic Acid (OA). The results show that under the same stimulation of PA + OA, compared with L02 cells in which the OTUD1 gene is normally expressed, red fat drops in the OTUD1 gene knockout L02 cells are large and much; in contrast, L02 cells over-expressed with OTUD1 gene had low and little red fat. The result shows that the OTUD1 gene can obviously inhibit liver lipid deposition and inhibit the occurrence of fatty liver. |
| priorityDate | 2018-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 162.