http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108210884-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate | 2018-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108210884-B |
| titleOfInvention | Application of ubiquitin-aldehyde binding protein 1 containing OTU functional domain in preparation of drugs for treating fatty liver and related diseases |
| abstract | The invention discloses application of ubiquitin-aldehyde binding protein 1 containing OTU functional domain in preparing a medicament for treating fatty liver and related diseases. The invention uses a normal human hepatocyte L02 cell line as a research object, and uses lentivirus to construct an OTUB1 knockout and overexpression vector system to obtain an OTUB1 gene knockout or overexpression L02 cell. The function of the OTUB1 gene in steatosis was studied by a fatty liver cell model induced by a combination of Palmitic Acid (PA) and Oleic Acid (OA). The results show that under the same stimulation of PA + OA, red fat droplets are much larger in OTUB1 knockout L02 cells compared to L02 cells in which OTUB1 gene is normally expressed; in contrast, L02 cells over-expressed with the OTUB1 gene showed small and few droplets of red fat. The result shows that the OTUB1 gene can obviously inhibit liver lipid deposition and inhibit the generation of fatty liver. |
| priorityDate | 2018-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 103.