| abstract |
The invention provides mice having a restricted immunoglobulin heavy chain locus characterized by a single polymorphic human VH gene segment, multiple human DH gene segments, and Multiple JH gene segments. The invention provides a method for producing antibody sequences that bind to an antigen, such as a viral antigen, comprising immunizing a mouse with the antigen of interest, wherein the mouse comprises a single human V at the endogenous immunoglobulin heavy chain locus H gene segments, multiple human D H gene segments, and multiple J H gene segments. |