| abstract |
The present invention provides a kind of temperature sensitive organo-mineral complexing hydrogel material and preparation method, the material shaping ability is strong, is easy to fill defect, has osteogenic activity.By gathering（N N-isopropylacrylamides）The synthesis of grafted gelatin and compound being prepared of ion doping calcium phosphate ceramic nanofiber.Shapeable is using poly-（N N-isopropylacrylamides）Negative temperature sensitivity characteristic, gather（N N-isopropylacrylamides）Grafted gelatin aqueous solution, which has, to be formed the ability of hydrogel to realize under human body temperature.It is different according to the compound ratio of hydrogel and calcium phosphate ceramic nanofiber, appearance is the liquid of injectable filling, easily operated paste or paste, the effectively bone defect of filling irregular shape can preferably meet the needs of bone defect clinical treatment, meet the clinical characters of bone increment reparation. |