http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108191954-B
Outgoing Links
Predicate | Object |
---|---|
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-306 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-265 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-30 |
filingDate | 2017-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2021-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2021-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-108191954-B |
titleOfInvention | A protein target molecule and chemical small molecule co-crystallization method |
abstract | The invention discloses a method for co-crystallization of protein target molecules and chemical small molecules. The chemical small molecules are dissolved in an organic solvent to form a dissolving solution. After the dissolving solution is centrifuged to remove impurities, the supernatant is taken and dropped into a well plate. Add a solution mixed with a binder, a sustained release agent and a solubilizer, and after drying and solidifying, dropwise add a protein buffer solution containing a precipitant and a seed crystal to the dried and solidified molecules, at 4-20 ° C, neutral The co-crystallization culture is carried out in an environment, and the preparation method has the advantages of short time-consuming, simple operation, and high success rate, which is conducive to automatic and high-throughput ligand screening. |
priorityDate | 2017-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.