http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108164548-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5383 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 |
| filingDate | 2016-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108164548-B |
| titleOfInvention | Pyrimidomorpholine derivative and preparation method and application thereof |
| abstract | The invention belongs to the field of chemical medicine, and particularly relates to an anti-medullary thyroid cancer, anti-acute leukemia and anti-inflammatory small molecule compound, and a preparation method and application thereof. The invention aims to solve the technical problems that the selectivity of the medicines on the market for medullary thyroid carcinoma is poor, and the medicines are easy to generate drug resistance and toxic and side effects. The scheme for solving the technical problems is to provide the pyrimido morpholine derivative, wherein the derivative is mainly substituted at the 6-position of pyrimidine, and the structure of the derivative is shown as a formula I. The compound provided by the invention has the advantages of high activity of resisting medullary thyroid carcinoma, low toxic and side effects, and capability of overcoming clinical drug resistance, and has great value in drug development for medullary thyroid carcinoma. |
| priorityDate | 2016-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 718.