http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108164503-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_217f2be73fd6be0be36dd55803d3bec5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-335 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-335 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-277 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-341 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 |
| filingDate | 2018-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_201d5299ef75f889acaf4004819acec8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b840caa337ce7a953506f15a165f276 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_307053c4848981d0d93fb0da7bcf20aa |
| publicationDate | 2018-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108164503-A |
| titleOfInvention | A kind of heteroaromatic and the disubstituted benzenesulfonamides of alkyl side chain and its application in anti-influenza A virus medicament is prepared |
| abstract | The invention discloses a kind of heteroaromatic and the disubstituted benzenesulfonamides of alkyl side chain and its applications in anti-influenza A virus medicament is prepared, and belong to pharmaceutical technology field.Shown in the structure of benzenesulfonamides of the present invention such as formula (I), preparation includes the following steps：With R 1 Substituted bromomethyl compound and with R 2 Substituted methylamine compound is generated under the conditions of sodium hydride, N, N dimethylformamides with R 1 And R 2 3 ((2 ylmethyl of thiophene) amino) propanenitrile derivatives of substituent group；3 ((2 ylmethyl of thiophene) amino) propanenitrile derivatives so make acid binding agent in triethylamine, dichloromethane is made to generate heteroaromatic and the disubstituted benzenesulfonamides of alkyl side chain by sulfonylation under solvent condition.The benzenesulfonamides of the present invention, can effectively inhibit the duplication of influenza A virus, to the small toxicity of cell, available for preparing the drug of anti-influenza A virus. |
| priorityDate | 2018-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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