http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108164397-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4fb38ebd40c70e97cc5f1519c6699162 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C39-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C37-0555 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C39-245 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C39-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C37-055 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C39-08 |
| filingDate | 2018-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0125fe2919c5fa283c0e2bb335472302 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38bd69605976a1ff10cbc063ac957fbc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f109116fe149112a9dafc2b49af836b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_955197a5bc379146aac784a77e592b03 |
| publicationDate | 2018-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108164397-A |
| titleOfInvention | A class of catechol derivatives and preparation method thereof |
| abstract | The invention discloses a class of catechol derivatives and a preparation method thereof. The preparation method comprises the following steps: (1) using an aryl phenolic compound as a substrate and 2-chloro-5-nitropyrimidine as a guiding group. The redistilled tetrahydrofuran solvent ice bath is slowly added to sodium hydride under the condition of nitrogen gas to react to obtain the pyrimidine aryl phenolic compound intermediate; (2) using iodobenzenediacetic acid as the oxidant and palladium acetate as the catalyst to catalyze the pyrimidine The aryl compound intermediate is subjected to a C-H activation reaction in a solvent, drained, and chromatographically separated and purified to obtain an acetoxylated aniline derivative; (3) using hydrazine hydrate to dissolve the acetoxylated aniline derivative in THF Reaction in solvent, quenching, washing and extraction, drying, pumping to dryness, chromatographic separation and purification to obtain o-aminophenol derivatives. The first two steps of the present invention can be realized in one pot, and even small-scale mass production above the "gram" level can be achieved. |
| priorityDate | 2018-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.