http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108159394-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 |
| filingDate | 2018-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108159394-B |
| titleOfInvention | Application of PR-957 in preparing medicine for treating cerebral ischemia reperfusion injury |
| abstract | The invention provides application of PR-957 in preparing a medicine for treating cerebral ischemia-reperfusion injury. The technical scheme takes an MCAO animal model as an experimental object, and utilizes PR-957 to investigate the effect of immunoproteasome in ischemic stroke. The experimental result shows that PR-957 treatment can reduce phosphorylation level of STAT3, and further cause the reduction of transcription levels of ROR gamma t and IL-17, so that Th17 differentiation is inhibited, intracerebral inflammatory response is reduced, cerebral infarction volume is reduced, and neurological function deficiency is reduced. Therefore, PR-957 plays a key role in regulating the inflammatory state of helper T cells after ischemic stroke of mice and can be used as a therapeutic means for relieving brain injury after ischemic stroke. |
| priorityDate | 2018-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 244.