http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108159022-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5084 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-36 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 |
| filingDate | 2017-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108159022-B |
| titleOfInvention | A kind of doxorubicin and ABT-263 double drug nanocarrier and preparation method thereof |
| abstract | The invention discloses a dual-drug nano-carrier of doxorubicin and ABT-263, which is composed of the following effective components according to mass percentage: medical gelatin is 52-60%, ABT-263 is 1.5-3%, hyaluronic acid is 52-60% is 35-42%, adriamycin is 1.5-3%, and the sum of the mass percentages of the above components is 100%. The invention also discloses a preparation method of doxorubicin and ABT-263 dual-drug nanocarriers, The lipid-soluble drug ABT-263 was encapsulated with gelatin to obtain the inner core drug-loaded nanoparticles, and then the hyaluronic acid-doxorubicin hydrochloride drug-loaded nanoparticles were used to cross-link the surface hyaluronic acid with glutaraldehyde, and finally the EDC/NHS cross-linking method was used. The two kinds of drug-loading nanoparticles are connected to obtain double-drug nano-carrier particles with stable structure. The present invention solves the difficulty of simultaneously encapsulating the two drugs in the prior art and the problem that the particle size does not meet the requirements and the drug-carrying performance is relatively poor. question. |
| priorityDate | 2017-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.