Predicate |
Object |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1774 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70532 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
filingDate |
2016-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2021-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate |
2021-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CN-108137671-B |
titleOfInvention |
Soluble PDL-1 molecules |
abstract |
The present invention provides a PDL-1 molecule having an affinity for a PD-1 molecule which is at least 2 times higher than the affinity of a wild-type PDL-1 molecule for a PD-1 molecule. Meanwhile, the PDL-1 molecule can effectively improve the killing capacity of lymphocytes. In addition, the invention provides nucleic acids encoding the PDL-1 molecules of the invention, as well as complexes of the PDL-1 molecules of the invention. The PDL-1 molecules of the present invention can be used alone or in combination with other molecules. |
priorityDate |
2015-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |