http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108129555-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 2017-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108129555-B |
| titleOfInvention | Design of polypeptide specifically binding to immune protein of pseudomonas aeruginosa hexa-type secretion system and verification of antibacterial activity of polypeptide |
| abstract | The invention discloses design of a polypeptide specifically combined with pseudomonas aeruginosa hexa-type secretion system immune protein and verification of antibacterial activity of the polypeptide. The invention firstly protects a polypeptide which is shown as a sequence 3 in a sequence table or a polypeptide which is shown as a sequence 4 in the sequence table. The gene encoding the polypeptide also belongs to the protection scope of the invention. The invention also protects the application of the polypeptide: binding to an immunity protein in a bacterial type vi secretion system; enriching immune proteins in a bacterial type VI secretion system; and (3) detecting immune protein in the bacterial VI type secretion system. The functional short peptide provided by the invention can be competitively combined with an effector protein to an immune protein, so that the TpLE-TpLEi interaction is damaged, the effector protein is promoted to crack the cell membrane of the bacterium to cause the bacterium to die, the novel antibacterial strategy which takes the T6SS effector protein as a target point is the most powerful, and a new direction is provided for the treatment of clinical drug-resistant strains. |
| priorityDate | 2017-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 498.