http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108129525-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate | 2017-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108129525-B |
| titleOfInvention | A kind of preparation method of etoposide intermediate |
| abstract | The invention discloses a preparation method of an etoposide intermediate. The method takes 4,6-O-acetal-D-glucose as the starting material, reacts with benzyl chloroformate in the presence of an acid binding agent, and obtains 4,6-O-acetal in high yield -1-O-benzyloxycarbonyl-β-D-glucose, then through 2,2-dichloroacetyl chloride diesterification, finally through palladium-carbon catalytic reduction to obtain etoposide intermediate 2,3-bis-O-( 2,2-dichloroacetyl)-4,6-O-ethylidene-β-D-glucopyranose. The invention has cheap and easy-to-obtain raw materials, simple and convenient operation, mild reaction conditions, high reaction yield, high product purity, less environmental pollution, and is suitable for industrial production. |
| priorityDate | 2017-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.