http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108129409-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D253-075 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D253-075 |
| filingDate | 2018-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108129409-B |
| titleOfInvention | Improved method for synthesizing lamotrigine |
| abstract | The invention discloses an improved method for preparing lamotrigine, which comprises the following steps: step I: 3-amino-1, 2, 4-triazine (I) and a halogenating reagent are subjected to halogenation reaction in the presence of an organic solvent to obtain 3-amino-6-halogeno-1, 2, 4-triazine (II); step II: the compound II is subjected to amination reaction to prepare 3, 5-diamino 6-halogeno-1, 2, 4-triazine (compound III); step III: the compound III and 2, 3-dichlorobenzene boric acid derivative are subjected to suzuki coupling reaction in a solvent under the catalysis of palladium/[ N, N ] pyridine amidino ligand/alkali to prepare the lamotrigine (IV). The method does not use metal cyanide, and has better reaction selectivity and higher reaction yield. |
| priorityDate | 2018-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 112.