| abstract |
The application relates to the field of drug synthesis, in particular to a preparation method of an anamorelin intermediate. On the one hand, this application uses 1-boc-1-methylhydrazine as the reaction raw material, and uses the method of alternate reaction of formaldehyde compound and palladium catalyst/hydrogen source to prepare the key intermediate N,N',N'-trimethylhydrazinecarboxylate Acid tert-butyl ester, the method is simple to operate, the raw materials used are safe and easy to get, and the yield is improved compared with the prior art method; The reaction of tert-butyl ester and hydrochloric acid in an organic solvent can directly obtain the crystalline product of N,N,N'-trimethylhydrazine hydrochloride with high yield and high purity. Preservation, very suitable for industrial mass production. |