| abstract |
The invention belongs to the field of drug synthesis, and in particular relates to an osimertinib intermediate and a preparation method thereof. The osimertinib intermediate provided by the present invention, the compound of formula C, has the following structural formula: R is an alkyl group or an aryl group; R 1 is an alkyl group, more preferably, a methyl group. After the compound of formula C is hydrolyzed, compound F is prepared through condensation reaction with the compound of formula E, Wherein, R is an alkyl group or an aryl group. R 1 is an alkyl group, more preferably a methyl group. |