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filingDate 2017-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-108126209-B
titleOfInvention Nano drug delivery system for time-sequence release of curcumin and chemotherapeutic drugs and application thereof
abstract The invention discloses a nano drug delivery system capable of releasing curcumin and chemotherapeutic drugs in a time sequence manner and application thereof in the aspect of tumor resistance. The invention adopts PEG to modify the chemotherapeutic drug to form amphiphilic conjugate, then coats curcumin to form a nano drug delivery system, the nano drug delivery system has the function of time sequence drug release, can release curcumin and the chemotherapeutic drug according to time sequence, and can be further modified by target molecules with tumor cell specificity to obtain the functions of tumor passive targeting, active targeting and time sequence drug release, and the nano drug delivery system has the excellent characteristics of drug resistance, tumor resistance and the like and has better clinical application prospect.
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