| abstract |
" chemical coupling product of TNF alpha muteins and formalin-inactivated OMP carrier proteins and preparation method thereof " of the invention provides target tumor necrosin ＆（TNF‑α）Proteantigen of vaccine preparation and its preparation method and application.Specifically, the proteantigen of " chemical coupling product of TNF alpha muteins and formalin-inactivated OMP carrier proteins and preparation method thereof " of the invention includes the hTNF alpha-mutants albumen of recombinant expression and the Bacterial outer membrane proteins P64K of recombinant expression, and the two is coupled with glutaraldehyde.After the proteantigen is shared with aluminum hydroxide adjuvant, there is strong immunogenicity, mouse can be excited to generate the immune response for being significantly directed to people TNF α. |