http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108125983-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-06 |
| filingDate | 2018-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108125983-B |
| titleOfInvention | Application of tanshinone IIA intervened mesenchymal stem cell transplantation in resisting Alzheimer disease neuroinflammation |
| abstract | The invention relates to application of tanshinone IIA intervened mesenchymal stem cell transplantation for resisting Alzheimer disease neuroinflammation, which comprises the steps of firstly separating and culturing MSC, interveneing the MSC for 48-84 h by using tanshinone IIA with the concentration of 6-12 mu M, verifying the effect of the tanshinone IIA intervened MSC transplantation for resisting Alzheimer disease neuroinflammation through an animal model, adopting A β 25‑35 Establishing an AD rat model by a rat lateral ventricle injection method, positioning and quantitatively inoculating sufficient MSC treated by tanshinone IIA to a hippocampus part of an AD model rat, and evaluating the learning and memory capacity of the AD model rat by applying a Morris water maze; taking tissues such as brain, serum, etc., measuring immune organ index, oxidation/oxidation resistance related index, apoptosis, and detecting the expression of nerve injury and regeneration related gene and protein; the result shows that the MSC transplantation intervened by tanshinone IIA has obvious effect of resisting the neuroinflammation of the Alzheimer disease. |
| priorityDate | 2018-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 187.