| abstract |
The present invention relates to the application of alkynephenylbenzenesulfonamide compounds with the structure of formula (I) or pharmaceutically acceptable salts or stereoisomers or prodrug molecules thereof in the preparation of ZAK inhibitors. The alkyne phenylbenzene sulfonamide compound can effectively and highly selectively inhibit ZAK protein kinase, and then regulate the activation of multiple pathways such as JNK/SAPK, p38, ERK, etc. downstream, and can be used for the preparation and prevention of ZAK kinase-related multiple Drugs for various diseases, such as myocardial hypertrophy, myocardial fibrosis, angina pectoris, coronary heart disease, heart failure, myocardial infarction, etc., have good pharmacokinetics and low toxicity, and have high druggability. |