http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108107103-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N27-64 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-64 |
| filingDate | 2017-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108107103-B |
| titleOfInvention | Mass spectrum probe of glutamate receptor and method for detecting spatial distribution rule of glutamate receptor in brain tissue |
| abstract | The invention relates to a mass spectrum probe of a glutamic acid receptor and a method for detecting the spatial distribution rule of the mass spectrum probe in brain tissue. The glutamic acid receptor mass spectrum probe consists of two parts, wherein one part is glutamic acid, N-methyl-aspartic acid, tert-butyl protected glutamic acid or N-methyl-aspartic acid, and the other part is a fluorenylmethoxycarbonyl group. The invention utilizes the photoelectron tunneling effect generated by the semiconductor nano material under the laser irradiation and the electron capture capacity of electrophilic groups in the mass spectrum probe molecules, photogenerated electrons are captured by electron-deficient atoms in the electrophilic groups and cause the breakage of adjacent alpha-position chemical bonds, different mass spectrum probe molecules generate the same fragment ions m/z165.0702Da, and the quantitative comparison of the space distribution of different probe molecules can be realized by measuring the signal intensity; the mass spectrometry probe molecule can be combined with a specific active cavity of a glutamic acid receptor, has the capacity of penetrating a blood brain barrier, and can provide a new idea and a new technology for drug screening. |
| priorityDate | 2017-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 19.