http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108107018-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-359 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-359 |
| filingDate | 2017-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108107018-B |
| titleOfInvention | In-situ real-time monitoring method for macromolecular polypeptide preparation based on gastrointestinal digestion |
| abstract | The invention discloses an in-situ real-time monitoring method for macromolecular polypeptide preparation based on gastrointestinal digestion, and belongs to the field of online monitoring of a protein enzymolysis process. The method comprises the following steps: carrying out enzymolysis on a milk protein solution, sampling an enzymolysis solution, carrying out gastrointestinal digestion, then measuring the blood pressure reduction activity of the enzymolysis solution, and simultaneously quickly collecting an in-situ real-time spectrum of the enzymolysis solution before collecting the enzymolysis solution. The spectrum is preprocessed, the optimal spectrum interval is screened, and a correction model and a prediction model are established by adopting a combined interval partial least square method. The prediction model is used for carrying out in-situ real-time monitoring and reaction end point judgment on the enzymolysis process, and the result shows that the prediction model is very close to the actual measurement model, so that the effective in-situ detection of the hydrolysis degree and the biological activity of an enzymolysis product after gastrointestinal digestion in the preparation of the milk protein macromolecule enzymolysis process can be realized. |
| priorityDate | 2017-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.