http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108103090-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2810-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-80 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-711 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-79 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-711 |
| filingDate | 2017-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108103090-B |
| titleOfInvention | RNA Cas9-m6A modified vector system for targeting RNA methylation, and construction method and application thereof |
| abstract | The invention discloses a 6-methyladenine modified vector system targeting mRNA, which comprises a protein expression vector of inactivated Cas9 nuclease fused with an enzymatic activity functional region of 6-methyladenine modified enzyme, a sgRNA expression vector targeting at least one site in the 3' UTR region of mRNA of CDCP1, and an oligonucleotide mismatched with the mRNA serving as a target. Meanwhile, the invention also discloses a preparation method and application of the mRNA-targeted 6-methyladenine modified vector system. By adopting the 6-methyladenine modified carrier system, the 6-methyladenine can be modified in a targeted manner for diseases caused by RNA 6-methyladenine modification abnormality, the accuracy and the high efficiency are realized, and the diseases caused by RNA modification defects can be fundamentally treated. |
| priorityDate | 2017-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.