http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108101910-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 |
| filingDate | 2017-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108101910-B |
| titleOfInvention | N-substituted pyrazolo [3,4-d ] pyrimidone compound and preparation method and application thereof |
| abstract | The invention provides an N-substituted pyrazolo [3,4-d]Pyrimidone compounds and preparation method and application thereof. The structure of the compound is shown as the formula (I): (ii) a Wherein R is selected from aliphatic hydrocarbon, aromatic ring, acyl-containing group, hydroxyl-containing group or sulfhydryl-containing group; r 1 Selected from methoxy, ethoxy, methyl, ethyl, halogen, chloromethyl, trifluoromethyl, acetyl, cyano, nitro, N-dimethyl, benzyloxy, substituted or unsubstituted amino, substituted guanidino, substituted or unsubstituted phosphate, substituted or unsubstituted sulfo, substituted or unsubstituted long-chain aliphatic alkane or substituted or unsubstituted long-chain aliphatic amine. The N-substituted pyrazolo [3,4-d ] of the invention]The pyrimidone compounds have certain inhibition effect on multiple phosphodiesterase subtypes, especially show good inhibition activity on PDE5A and PDE9A, can be used as phosphodiesterase multi-subtype inhibitors, and have good application prospect in the aspect of treating Alzheimer disease and type II diabetes. |
| priorityDate | 2017-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 240.