http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108101892-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2017-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108101892-B |
| titleOfInvention | Chrysin non-natural amino acid derivative and preparation method and application thereof |
| abstract | The invention discloses chrysin unnatural amino acid derivatives or pharmaceutically acceptable hydrates and salts thereof, including stereoisomers or tautomers thereof. The preparation method comprises the following steps: the chrysin and bromopropyne are subjected to alkali action to prepare 5-hydroxy-7-propargyloxy flavone; (L/D) -halo-Boc amino acid methyl ester with NaN 3 Preparing (L/D) -N under the action of CuI/L-sodium prolinate 3 -Boc amino acid methyl ester; 5-hydroxy-7-propargyloxyflavone and (L/D) -N 3 -Boc amino acid methyl ester and then CuSO 4 .5H 2 Reacting under the action of O/sodium ascorbate, removing Boc group, and hydrolyzing to obtain chrysin amino acid derivative. The chrysin non-natural amino acid derivative has an anti-cancer effect and can be used for treating anti-cancer drugs. |
| priorityDate | 2017-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.