http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108096571-B
Outgoing Links
Predicate | Object |
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classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55583 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-6087 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5161 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-06 |
filingDate | 2017-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2021-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2021-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-108096571-B |
titleOfInvention | Tuberculosis polypeptide vaccine for preventing and treating tuberculosis and preparation method and application thereof |
abstract | The invention relates to a tuberculosis polypeptide vaccine for preventing and treating tuberculosis, a preparation method and application thereof, and belongs to the technical field of biological pharmaceutical engineering. The tuberculosis polypeptide vaccine comprises tuberculosis polypeptide and a carrier, wherein the tuberculosis polypeptide comprises one or more of 81-100 amino acid fragments of mycobacterium tuberculosis Rv0180c protein, 261-280 amino acid fragments of Rv0227c protein and 281-300 amino acid fragments of Rv2004c protein. The selected polypeptide fragments are key polypeptide fragments in MTB important protective antigens, main protective epitopes of a plurality of antigens are concentrated, the polypeptide fragments can be tightly combined with susceptible cells, mycobacterium tuberculosis H37Rv can be effectively prevented from invading the cells, the natural structures and the hydrophilicity of the three sections of polypeptides are good, the polypeptide fragments are suitable for artificial synthesis, and chitosan-deoxycholic acid conjugates are used as carriers, so that the effective humoral immunity and cellular immune response of organisms can be stimulated. |
priorityDate | 2017-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 486.