http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108096213-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6305b3e7621b48988930d891844fdda |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5036 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5089 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-366 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-366 |
| filingDate | 2017-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35deee6c80918f3cbdab4c675dea46c6 |
| publicationDate | 2018-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108096213-A |
| titleOfInvention | Preparation method of simvastatin microspheres coated with hydroxyethyl starch 130/0.4 |
| abstract | The invention discloses a preparation method of simvastatin microspheres coated with hydroxyethyl starch 130/0.4, and relates to the technical field of organic preparation of drug microspheres. Using simvastatin as the starting material, the surface of simvastatin is chemically modified by plasma through H 2 O/O 2 mixed gas, and then a layer of hydroxyethyl group is coated on the surface of simvastatin after surface plasma chemical modification. Starch 130/0.4 forms simvastatin microspheres coated with hydroxyethyl starch 130/0.4; the main steps of the preparation method include: 1) plasma chemical modification of the surface of simvastatin; 2) hydroxyethyl starch 130/0.4 The surface of the simvastatin chemically modified by surface plasmon is wrapped. The hydroxyethyl starch 130/0.4-coated simvastatin microspheres prepared by the preparation method have the advantages of uniform particle size distribution, large drug loading capacity, high drug encapsulation rate, good drug release stability, safety and reliability, and the like. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110665049-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110665049-A |
| priorityDate | 2017-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.