http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108096199-B
Outgoing Links
Predicate | Object |
---|---|
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-26 |
filingDate | 2018-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2020-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2020-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-108096199-B |
titleOfInvention | Omeprazole sodium for injection and preparation method thereof |
abstract | The invention discloses omeprazole sodium for injection and a preparation method thereof, wherein the preparation raw materials comprise omeprazole sodium, mannitol, a complexing agent, a pH regulator and water for injection, the raw materials are dissolved by the water for injection to prepare liquid, and then freeze-drying is carried out, and the raw materials also comprise Tween 40. The freeze-drying process parameters are as follows: pre-freezing at minus 45 ℃ for 2 hours, keeping the vacuum degree below 20Pa, sublimating at the low temperature of minus 45 ℃ to minus 5 ℃ for 3 hours, keeping the vacuum degree at 20-30 Pa, analyzing and drying at 25 ℃ for 3 hours, and keeping the freeze-drying period for 12 hours. The omeprazole sodium for injection provided by the invention obviously reduces the freeze-drying time by optimizing the prescription and the preparation process, shortens the time from 25-50 hours to 12 hours in the prior art, not only can save energy consumption, but also obviously reduces the probability of failure of the freeze-drying procedure, and avoids the loss of raw materials caused by the interruption of the freeze-drying period. |
priorityDate | 2018-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 261.