http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108084082-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-86 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-88 |
| filingDate | 2017-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108084082-B |
| titleOfInvention | Method for synthesizing [ b ] -cyclized indole derivatives |
| abstract | The invention discloses a method for synthesizing [ b ] -cyclic indole compounds, which comprises the following steps: under the action of a palladium catalyst, norbornene is used as a transient guide medium, dihalogenated alkane is used as an alkylation reagent, and under the action of alkali, domino reaction of indole C2 and C3 site alkylation ring closure is realized in sequence by one pot, so that the [ b ] -cyclic indole compound is effectively synthesized. The method has mild conditions, directly uses commercially available indole as a substrate, omits a pre-functionalization process, reduces reaction steps, has high atom economy, modifies a simple small indole molecular structure, and can be further used for researches such as medicine or total synthesis, and the like, and has high potential value and wide application prospect in the fields of pharmaceutical chemistry and the like. |
| priorityDate | 2017-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 68.