http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108078924-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1273 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 |
| filingDate | 2017-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108078924-B |
| titleOfInvention | Preparation method of polyethylene glycol-modified pH-responsive nano micelle or vesicle with high drug loading capacity |
| abstract | The invention belongs to the fields of high molecular materials and biomedical engineering, and particularly relates to a preparation method of polyethylene glycol modified nano micelle or vesicle with high drug loading capacity and pH responsiveness. The specific method comprises the following steps: polyethylene glycol and cis-aconitic anhydride modified doxorubicin are reacted to generate an amphiphilic block copolymer, and the pH-responsive high-drug-loading-rate nano micelle or vesicle with the anticancer drug doxorubicin as a hydrophobic chain segment and the polyethylene glycol as a hydrophilic chain segment is formed. The nano micelle or vesicle takes an anticancer drug as a hydrophobic chain segment, so that the nano micelle or vesicle has higher drug loading capacity, and meanwhile, cis-aconitic anhydride is sensitive to acid, so that the prepared nano micelle or vesicle has pH responsiveness, is suitable for the field of tumor treatment, can improve the chemotherapy efficiency, and reduces the toxic and side effects of the anticancer drug on normal tissues. |
| priorityDate | 2017-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.