| abstract |
The present invention relates to 3-pyridyl-4-benzothiazolyl pyrazole derivatives, their preparation method and their application in medicine. Specifically, the present invention relates to a new 3-pyridyl-4-benzothiazolyl pyrazole derivative shown in general formula (I), a preparation method thereof and a pharmaceutical composition containing the derivative and Its use as a therapeutic agent, especially as a TGF-beta inhibitor and in the manufacture of a medicament for the treatment, prevention or reduction of cancer mediated by TGF-beta overexpression, wherein each substituent of the general formula (I) is The definitions in the specification are the same. |