http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108066313-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-4866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01F35-71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01F27-90 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01F7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01F15-02 |
| filingDate | 2017-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108066313-B |
| titleOfInvention | Preparation method of metformin hydrochloride clathrate |
| abstract | The invention relates to a preparation method of a metformin hydrochloride clathrate compound, which comprises the following steps: s1, adding a suspension dispersant into distilled water, and stirring to prepare a suspension; s2, adding metformin hydrochloride into the suspension, stirring, increasing the stirring speed, sequentially adding methyl methacrylate, styrene and a BPO initiator, gradually heating to 80 ℃, stopping heating, naturally reacting, heating while still stirring, gradually clathrating the metformin hydrochloride, and naturally cooling to room temperature after the reaction to form fine powder; s3, washing with purified water until the water drops of the washed water are clear; s4, spin-drying the cleaned fine powder, and drying the fine powder into dry fine powder; s5, screening out dry fine powder of 200 meshes by using a filter screen; s6, filling the empty capsules with the dry fine powder to form hard capsules. Also discloses equipment for preparing the metformin hydrochloride clathrate compound. The invention achieves the following beneficial effects: small side effect, high safety, convenient full play of the medicine and small difference of the drug effect among single amount of the medicine. |
| priorityDate | 2017-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 101.